Annular Elastolytic Giant Cell Granuloma Successfully Treated with Minocycline Hydrochloride.

نویسندگان

  • Ai Nanbu
  • Kazumitsu Sugiura
  • Michihiro Kono
  • Yoshinao Muro
  • Masashi Akiyama
چکیده

Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterised by small papules that evolve into annular/polycyclic plaques. Plaques typically have a slightly raised border; the centre may be hypopigmented and/or atrophic. Lesions are usually located on sun-exposed areas such as the face and the neck (1, 2). Histologically, AEGCG is associated with multinucleated giant cell infiltrate, elastolysis, and elastophagocytosis, localised mainly in the mid-dermis. Elastophagocytosis is considered to be brought on by one or more triggers, which leads to the loss of elastic fibres (3); in AEGCG, the possible triggers include ultraviolet radiation, heat, or other unknown factors that induce a cellular immune response (4). AEGCG is often refractory to any treatment, and no standard therapy has been established (5). Here, we report a case of AEGCG that improved after 11 weeks of treatment with oral minocycline hydrochloride.

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عنوان ژورنال:
  • Acta dermato-venereologica

دوره 95 6  شماره 

صفحات  -

تاریخ انتشار 2015